BENNANI, YOUSSEF L.,约瑟夫L. 班那尼,約瑟夫L. 班那尼,ROBARGE, MICHAEL J.,麦可J. 罗巴奇,麥可J. 羅巴奇,BOM, DAVID C.,大卫C. 彭,大衛C. 彭
申请号：
TW094130443
公开号：
TWI406866B
申请日:
2005.09.05
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are hexahydroazepinoindole and octahydroazepinoindole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).本發明一般而言係關於一系列之化合物、含有該等化合物之醫藥組合物,以及該等化合物和組合物作為治療劑之用途。更特定而言,本發明之化合物為四氫氮呯并吲哚(hexahydroaZepinoindole)和八氫氮呯并吲哚(octahydrozepinoindole)化合物。該等化合物為血清素受體(5-HT)配位基以及可用於治療需要調節血清素受體(5-HT)活性之疾病、異常和情況(例如焦慮憂鬱和肥胖)。
