Various embodiments of a wound cover apparatus are provided. In one embodiment a wound cover apparatus includes a treatment enclosure and a vacuum seal that is external to the treatment enclosure. The vacuum seal includes a vacuum passageway and a vacuum port in fluid communication with one another. In another embodiment the apparatus further includes a treatment port in fluid communication with the treatment enclosure. The wound cover apparatus adheres to the patient by application of vacuum applied to the treatment enclosure and the vacuum seal which extends from the housing. The negative pressure applied to the wound cover apparatus creates negative stress along periwound which promotes perfusion and vascularization and induces mechanical deformation to accelerate healing.