John Fraser Wright;Olga Zelenaia;Bernd Hauck;Federico Mingozzi;Katherine A. High
发明人:
John Fraser Wright,Olga Zelenaia,Bernd Hauck,Federico Mingozzi,Katherine A. High
申请号：
US13985351
公开号：
US10392632B2
申请日:
2012.02.14
申请国别(地区):
US
年份:
2019
代理人:
摘要：
This application relates to the fields of gene therapy and molecular biology. In accordance with the present invention, an adeno-associated virus (AAV) vector comprising an altered capsid protein is provided. More specifically, this invention provides adeno-associated viral vectors comprising protein capsid variants which accelerate vector breakdown and clearance, thereby reducing undesirable immune responses.
