Disclosed are chemical entities of Formula (I): wherein R1 and Z are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).本文揭示式(I)之化學實體，其中R1及Z係本文所定義，其係做為NR2B亞型選擇性受體拮抗劑。本文亦揭示包含式(I)之化學實體之醫藥組合物，及藉由投與式(I)之化學實體治療與NR2B拮抗作用相關之各種疾病及病症(例如CNS之疾病及病症，例如抑鬱症)之方法。
