The present application relates to a system for ophthalmic intervention on an eye of a patient, comprising a detection device having a detection field oriented toward the eye of the patient, a patient interface housing having proximal and distal ends and defining a passage therethrough, wherein the distal end is coupled to one or more seals configured to be directly engaged with one or more surfaces of the eye of the patient, and wherein the proximal end is configured to be coupled to a patient workstation such that at least a portion of the detection field of the detection device passes through the passage; and two or more registration fiducials coupled to the patient interface housing in a predetermined geometric configuration relative to the patient interface housing within the detection field of the detection device such that the registration fiducials can be located by the detection device in reference to predetermined geometric markers on the eye of the patient, the system being operable to locate the geometric markers.