LEWIS EVAN,SHWONEK PETER,DALZIEL SEAN,JUMAA MOUHANNAD
申请号：
IN8098/DELNP/2012
公开号：
IN2012DN08098A
申请日:
2012.09.17
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
This disclosure provides methods for formulating compositions comprising one or more peptide proteasome inhibitors and a cyclodextrin particularly a substituted cyclodextrin. Such methods substantially increase the solubility and stability of these proteasome inhibitors and facilitate both their manufacture and administration. Many peptide proteasome inhibitors have been shown to have low solubility in water.
