MIN, CHANG HEE,KIM, YONG EUN,OH, BYUNG KYU,LEE, JI SUN,HEO, HYE JIN,OH, JU HOON,CHO, WOONG
申请号：
EP14748929
公开号：
EP2941418A4
申请日:
2014.02.06
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention provides an N1-cyclic amine-N5-substituted biguanide derivative compound represented by Formula 1, a method of preparing the same and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient. The biguanide derivatives have an effect of inhibiting cancer cell proliferation, cancer metastasis and cancer recurrence by activation of AMPK, even when administered in a small dose compared with conventional drugs.
