This invention discloses stable, small volume parenteral dosage form with higher systemic bio-availability and lower toxicity of sodium aminosalicylate. This lyophilized formulation comprises combination of sodium aminosalicylate, polyvinyl pyrrolidone and stabilizers. The formulation is stable at temperature less than 30 degree celsius for at least 3 years. The small volume parenteral formulation has a short reconstitution time of less than 1 minute, and is suitable for parenteral administration through various routes such as intravenous, intramuscular, intraperitoneal, or subcutaneous.
