Implantable systems, and methods for use therein, for monitoring for mitral valve regurgitation (MR) are provided. An electrogram (EGM) signal and a corresponding pressure signal are obtained, where the EGM signal is representative of electrical functioning of the patients heart during a plurality of cardiac cycles, and the corresponding pressure signal is representative of pressure within the left atrium the patients heart during the cardiac cycles. Windows of the pressure signal are defined, based on events detected in the EGM signal, and measurements from the windows are used to monitor for MR.
