AN INGESTIBLE THERAPY ACTIVATOR SYSTEM AND METHOD ARE PROVIDED. IN ONE ASPECT, THE INGESTIBLE THERAPY ACTIVATOR (102) INCLUDES AN INGESTIBLE DEVICE (200) HAVING AN EFFECTOR MODULE (202) TO SEND AN EFFECTOR INSTRUCTION (204) AND A RESPONDER MODULE (206) ASSOCIATED WITH A THERAPEUTIC DEVICE (108). THE RESPONDER MODULE (206) MAY RECEIVE AND PROCESS THE EFFECTOR INSTRUCTION (204), RESULTING IN A RESPONSE BY THE THERAPEUTIC DEVICE (108). EXAMPLES OF RESPONSES BY THERAPEUTIC DEVICE (108) INCLUDE ACTIVATING A THERAPY, DEACTIVATING A THERAPY, MODULATING A THERAPY, AND DISCONTINUING A THERAPY.