Methods for producing stem cells improved by modulating placental RNA molecules. In addition, Methods of using placental stem cells improved, for example, to treat Individuals with a disease, disorder or condition caused by or related to unwanted or harmful immune responses. Also compositions comprising these placenta stem cells Enhanced.Claim 1: a method for treating an individual who has or is at risk of developing a disease, disorder or a condition with an inflammatory Component, which comprises administering to the individual a therapeutically effective amount of placental stem cells improvedWhere these cells are or were in contact with an effective amount of modulatory RNA molecules that (i) deleted a number of il-23 soluble Protein produced by peripheral blood mononuclear Cells (PBMC) in the presence of placental stem cells improved； (ii) increase.Activity of Cyclooxygenase 2 (COX 2) in placental stem cells improved； (iii) increase the amount of PGE2 produced by placental stem cells improved； or (iv) reduce the level of proinflammatory cytokine produced by placental stem cells improved compared The placental stem cells not in contact with the modulating Molecules of RNAWhere the therapeutically effective amount is an amount sufficient to cause a detectable Improvement of one or more symptoms of the disease, disorder or condition.Métodos para producir células madre de placenta mejorada por moléculas de ARN moduladoras. Además métodos para usar células madre de placenta mejoradas, por ejemplo, para tratar individuos con una enfermedad, trastorno o condición causada por, o relacionada con respuestas inmunes no deseadas o dañinas. También composiciones que comprenden dichas células madre de placenta mejorada. Reivindicación 1: Un método para tratar a un individuo que padece o que está en riesgo de desarrollar una enfermedad, un trastorno o una afección con un componente inflamatorio, que comprende administrar al individuo una cantidad terapéuticamente eficaz de cé
