Antibodies that neutralize Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting the bone.Linvention concerne des anticorps qui neutralisent Notum Pectinacetylesterase, ainsi que des compositions les comprenant, et les procédés de leur utilisation pour traiter des maladies et des troubles affectant les os.