The present invention relates to a contraceptive method with reduced cardiovascular effects, such as reduced thromboembolism risk, such as reduced venous thromboembolism (VTE) risk and reduced aortic thromboembolism (ATE) risk.The method of the invention comprises administering to a female mammal an effective amount of an estetrol component in combination with a progestogenic component. The method enjoys a favourable profile for thromboembolism compared to currently available methods which employs contraceptives from the so-called second, third or fourth generation.本案涉及具有降低心血管效應的避孕方法，例如降低的血栓栓塞風險、如降低的靜脈血栓栓塞(venous thromboembolism，VTE)和降低的主動脈血栓栓塞(aortic thromboembolism，ATE)的風險。本案之方法包括對雌性哺乳動物施以有效量的雌四醇成分與助孕素成分的組合。與現有使用所謂的第二代、第三代或第四代避孕藥的方法相比，本方法對血栓栓塞具有良好的性質。
