The Board of Trustees of the Leland Stanford Junior University
发明人:
Geoffrey C. Gurtner,Michael T. Longaker,Victor W. Wong
申请号：
US13706186
公开号：
US20130165463A1
申请日:
2012.12.05
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The formation of scars at a wound site is reduced by contacting the wound site with an effective dose of an inhibitor of focal adhesion kinase (FAK) activity or expression. Blockade of FAK is sufficient to prevent mechanical and inflammatory stimuli from activating MCP-1 pathways. In addition to these chemokine-mediated mechanisms, inhibition of FAK may control fibrosis by blocking fibroblast collagen production. Pharmacologic blockade of FAK significantly reduces scar formation in vivo.
