KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
发明人:
LEE, HAE SHIN,이해신,LEE, MOON SUE,이문수,RYU, JI HYUN,류지현
申请号：
KR1020110121482
公开号：
KR1020130055847A
申请日:
2011.11.21
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A hydrogel, a manufacturing method thereof, and coagulator using the same are provided to include compound which combines catechol with chitosan or polyamine, compound which combines thiol group at both ends of polaxamer, and polaxamer combined with chitosan or polyamine combined catechol and thiol group combined at end part.CONSTITUTION: A hydrogel composition comprises chitosan or polyamine combined catechol and poloxamer combined thiol group at the end portion. The molecular weight of chitosan or polyamine combined the catechol is 10,000 Da to 1,000,000 Da. The molecular weight of chitosan or polyamine combined the catechol is 50,000 to 200,000. The polaxamer is a pluronic or a pluronic represented as the formula 2 and amphiphilic triblockcopolymer similarly structured or a tetronic represented as the formula 3.COPYRIGHT KIPO 2013본 발명은 카테콜기가 결합된 키토산 및 말단에 티올기가 결합된 플루로닉을 포함하는 접착성 하이드로젤 조성물에 관한 것으로, 보다 상세하게는 생체 내외에서의 안전성을 갖고, 온도 감응적이며, 지혈효과가 우수 하여 생체 접착제로서 이용 가능한 접착제 조성물 및 이를 포함하는 의료용 접착제, 유착 방지제 및 표면 흡착 방지제에 관한 것이다.
