The invention relates to a method for registration of diagnostic images taken for different time moments, comprising the steps of retrieving an earlier diagnostic image, retrieving a later diagnostic image, registering the earlier diagnostic image and the later diagnostic image, identifying differences between the earlier diagnostic image and the later diagnostic image, marking an area corresponding to a difference between the earlier and the later diagnostic image on the later diagnostic image. The invention further relates to a system and a computer program for registration of diagnostic images taken for different time moments.