NILAKSHI GOHAIN,PROF MOHAN CHANDRA KALITA,HRIDIP KUMAR SARMA,ANIL PRAKASH,D R BHATTACHARYYA,P K MOHAPATRA,KABITA GOGOI,J MAHANTA,NILANJU PRAN SARMA,CHANDRAJIT DOHUTIA
申请号：
IN1202/KOL/2014
公开号：
IN2014KO01202A
申请日:
2015.02.19
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention is related to the collection of an indigenous ethnomedicinal plant species Crinum asiaticum from Assam, India, preparation of crude extract from its bulbs using chloroform as a solvent and evaluating its antiplasmodial activity against Plasmodium falciparum, the major causative agent of human malaria. The in-vitro antiplasmodial activity screening was done against two references of P.falciparum strains, RKL-2(chloroquine resistant strain) and 3D-7(chloroquine sensitive strain), using schizont inhibition assays. The crude chloroform (moderately polar solvent) extract of the bulb of the plant species Crinum asiaticum was found to have a highly active antiplasmodial activity against both the strains of P.falciparum mentioned above. The herbal formulation of Crinum asiaticum and another plant Curanga amara juss had showed very promising antiplasmodial activity. The formulation did not show any toxicity on animal model and mammalian RBCs.
