Create manner of sick condition model laboratory animal and sick condition model laboratory animal and utilization manner of sick condition model laboratory animal.
< Topic >From the fatty liver the human non alcoholic characteristic chronic hepatitis of progression and/or liver tissue conversion and/or are the new sick condition model laboratory animal and its production method and offer the utilization method of the new sick condition model laboratory animal the times when the hepatic cirrhosis is reproduced.SolutionsIn vivo hypoxia state is made to form vis-a-vis the fatty liver support model laboratory animal, finally the non alcoholic characteristic fat characteristic hepatitis and/or biochemical feature of the hepatic cirrhosis and/or the sick condition model laboratory animal which maintains histopathology feature is produced.< Selective figure >It is not【課題】脂肪肝から進行性のヒト非アルコール性慢性肝炎及び/又は肝線維化及び/又は肝硬変を再現する新規病態モデル実験動物及びその作出方法と新規病態モデル実験動物の利用方法を提供することにある。【解決手段】脂肪肝担持モデル実験動物に対し生体内低酸素状態を形成させ、最終的に非アルコール性脂肪性肝炎及び/又は肝硬変の生化学的特徴及び/又は病理組織学的特徴を維持した病態モデル実験動物を作出する。【選択図】なし
