Imaging device (10) has an optical window (21) and includes illumination source (23), e.g. a white LED, CMOS imaging camera (24) and optical system (22) to focus images on the camera. The device also includes a transmitter (26) and antenna (27) for transmitting images to a system outside the patient's body. The device is capsule suitable for insertion into and passing through body lumens or cavities. Independent claims are also included for the following: (a) A swallowable capsule for in vivo imaging of the gastrointestinal tract; (b) A system for in vivo imaging; (c) In a device for in vivo imaging, a transmitter for transmitting signals from the CMOS imaging camera to a receiving system; (d) In a device for in vivo imaging, an illumination source for illuminating the site in vivo, and; (e) A method for imaging an in vivo site.