Medical devices and methods for making and using medical devices are disclosed. An example medical may include a guide catheter. The guide catheter may include an elongate catheter shaft having a proximal end, a distal end, and a central lumen extending therebetween. An inflatable locking member may be disposed within the lumen. The locking member may be configured to longitudinally secure the position of a medical device extending through the lumen relative to the catheter shaft. The guide catheter may also include an inflation lumen in fluid communication with the inflatable locking member.
