NOELLE RANDOLPH J,CEERAZ SABRINA,LEMERCIER ISABELLE,NOWAK ELIZABETH,LINES JANET LOUISE
申请号：
IN150/KOLNP/2015
公开号：
IN2015KN00150A
申请日:
2015.01.16
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to a fusion proteins comprising regulatory T cell protein VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig), preferably also containing a flexible linker intervening the VISTA and Ig Fc polypeptide. The invention also provides the use of VISTA polypeptides multimeric VISTA polypeptides VISTA-conjugates (e.g., VISTA-Ig), and VISTA antagonists for the treatment of autoimmune disease, allergy, and inflammatory conditions, especially lupus, multiple sclerosis, psoriasis, psoriatic arthritis, multiple sclerosis, Crohn"s disease, inflammatory bowel disease and type 1 or type 2 diabetes.
