ADN DOUBLE HELICE LINEAIRE A EXTREMITE FERMEE POUR TRANSFERT DE GENE NON VIRAL

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专利权人:

UNIVERSITY OF MASSACHUSETTS

发明人:

KOTIN, ROBERT M.,CECCHINI, SYLVAIN

申请号：

CA3014683

公开号：

CA3014683A1

申请日:

2017.03.03

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

Aspects of the disclosure relate to a nucleic acid comprising a heterologousnucleic acid insert flanked by interruptedself-complementary sequences, wherein one self-complementary sequence isinterrupted by a cross-arm sequence forming two opposing,lengthwise- symmetric stem-loops, and wherein the other of the self-complementary sequences is interrupted by a truncatedcross-arm sequence. Methods of delivering the nucleic acid to a cell are alsoprovided.

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