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ADN DOUBLE HELICE LINEAIRE A EXTREMITE FERMEE POUR TRANSFERT DE GENE NON VIRAL
专利权人:
UNIVERSITY OF MASSACHUSETTS
发明人:
KOTIN, ROBERT M.,CECCHINI, SYLVAIN
申请号:
CA3014683
公开号:
CA3014683A1
申请日:
2017.03.03
申请国别(地区):
CA
年份:
2017
代理人:
摘要:
Aspects of the disclosure relate to a nucleic acid comprising a heterologousnucleic acid insert flanked by interruptedself-complementary sequences, wherein one self-complementary sequence isinterrupted by a cross-arm sequence forming two opposing,lengthwise- symmetric stem-loops, and wherein the other of the self-complementary sequences is interrupted by a truncatedcross-arm sequence. Methods of delivering the nucleic acid to a cell are alsoprovided.
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