MOLÉCULE DE LIAISON D'ANTIGÈNE DESTINÉE À FAVORISER LA DISPARITION D'ANTIGÈNE VIA LE RÉCEPTEUR Fc RIIB

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专利权人:

Chugai Seiyaku Kabushiki Kaisha

发明人:

申请号：

EP13751098.8

公开号：

EP2818183A1

申请日:

2013.02.22

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

The present invention provides antigen-binding molecules containing (i) an antigen-binding domain whose antigen-binding activity varies depending on ion concentration conditions, (ii) an Fcγ-binding domain having Fcγ RIIb-selective binding activity, and (iii) an FcRn-binding domain having FcRn-binding activity under an acidic pH range condition, and methods of decreasing plasma antigen concentration as compared to before administering the molecule, which include the step of administering the molecule.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/