A system for navigating to and interacting with a region of interest during a respiratory cycle is provided. The system includes an extended working channel, a computing device including a memory and at least one processor, a plurality of images stored in the memory, a display device that displays a user interface. The user interface includes at least one image of the plurality of images depicting the region of interest and a progression of the extended working channel through the airway, and a probability diagnostic and/or treatment zone defining a probable distribution of a trajectory of the tool once deployed beyond an opening of the extended working channel displayed in the at least one image. The respiratory cycle is divided into inhalation and exhalation. The user interface is configured to depict movement of the region of interest and the airways during the respiratory cycle.
