Claude Michel WISCHIK,John Mervyn David STOREY,Colin MARSHALL,James Peter SINCLAIR,Thomas Craven BADDELEY
申请号：
US15185803
公开号：
US20160296531A1
申请日:
2016.06.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds (“diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (Methylene Blue), and the resulting high purity characterized by a purity greater than 98%, and very low levels of heavy metals and organic impurities Azure A, B, C and MVB. Also disclosed are methods of treatment of a tauopathy or methemoglobinemia in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of the high-purity diaminophenothiazinium compound.
