The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.Anticorps anti-LRP6 et ses procédés d'utilisation. Un aspect particulier de l'invention concerne des anticorps anti-LRP bispécifiques qui inhibent la signalisation par de multiples isoformes Wnt.