The present disclosure relates to salts and compositions of isophosphoramidemustard and isophosphoramide mustard analogs. In one embodiment the salts canbe represented by the formula I: (I) wherein A+ represents an ammonium speciesselected from the protonated (conjugate acid) or quaternary forms of aliphaticamines and aromatic amines, including basic amino acids, heterocyclic amines,substituted and unsubstituted pyridines, guanidines and amidines； and X and Yindependently represent leaving groups. Also disclosed herein are methods formaking such compounds and formulating pharmaceutical compositions thereof.Methods for administering the disclosed compounds to subjects, particularly totreat hyperproliferative disorders, also are disclosed.
