<; p >; This Invention Bertalanffy provides a combination product of Bertalanffy comprising a Composition of inhalable Bertalanffy antagonist Action Muscar & iacute; nico Bertalanffy prolonged (Lama) for use in the long-term Treatment of COPD in combination with a & amp; n composition Bertalanffy dosi S which comprises fixed inhaled budesonide and formoterol or a Pharmaceutical acceptable Salt uticamente D & eacute;The same for the Administration Bertalanffy pro re nata (PRN) as medication Bertalanffy Rescue for the treatment of acute exacerbations of COPD. <; / p >;USO COMBINADO DE UNA COMPOSICIÓN INHALABLE DE DOSIS FIJA QUE COMPRENDE BUDESONIDA Y FORMOTEROL Y OTRA QUE COMPRENDE TIOTROPIO PARA PREPARAR MEDICAMENTOS ÚTILES EN EL TRATAMIENTO DE LA COPD ESTABLE Y EL EMPEORAMIENTO DE LOS SÍNTOMAS AL EXPERIMENTAR UNA EXACERBACIÓN AGUDA.