A system and method include an interface to: receive imaging data representing a plurality of X-ray images in a patient volume including vessels during an acquisition period； one or more processors operative to: generate a 3D image of the patient volume showing a contrast medium flowing through the patient volume； and analyzing the patient volume during the acquisition period based on the flow of the contrast medium as the contrast medium flows through the patient volume to determine a stenosis level in one or more vessels； a display to display the 3D image of the patient volume as the contrast medium flows through the patient volume； and a memory. Numerous other aspects are provided.
