The present invention provides a therapeutic agent for a lower urinary tract disease such as cystitis, interstitial cystitis, prostatitis, benign prostatic hyperplasia etc., which are considered as refractory disease, and an agent for improving a lower urinary tract symptom associated with the lower urinary tract disease.本発明は、難治性疾患とされている膀胱炎、間質性膀胱炎、前立腺炎、前立腺肥大症などの下部尿路疾患治療剤及びこれらの疾患に伴う下部尿路症状改善剤を提供する。【選択図】なし