POLYESTERS SUBSTITUÉS PAR MODIFICATION DE THIOL-ÈNE : DIVERSIFICATION RAPIDE POUR STABILISATION DE PROTÉINES THÉRAPEUTIQUES

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专利权人:

The Regents of the University of California

发明人:

申请号：

EP17210956.3

公开号：

EP3342796A1

申请日:

2017.12.28

申请国别(地区):

EP

年份:

2018

代理人:

摘要：

Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5-[R1R2C - CR3R4]n-[DG]m-R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (-OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups.

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