"Pharmaceutical composition for the treatment of osteoarthritis" The present invention relates to pharmaceutical compositions comprising chondroitin sulphate and an amino sugar, wherein the amino sugar is selected from the group consisting of mannosamine, a mannosamine derivative and mixtures thereof. The mannosamine derivative is preferably N- acetylmannosamine. The pharmaceutical compositions may further comprise glucosamine. Said compositions are disclosed for use as a medicament. In particular, said compositions are useful in the treatment or prevention of degenerative joint diseases, preferably of osteoarthritis, in the treatment or prevention of tendon or ligament diseases, disorders or injuries and of immune system diseases, preferably of rheumatoid arthritis.