An electronic stethoscope includes an acoustic sensor assembly having a first microphone to detect biological sounds within a body, a detection system in communication with the first microphone to receive an auscultation signal from the first microphone, the auscultation signal including information of the biological sounds detected by the first microphone. The stethoscope also includes a second microphone in communication with the detection system to detect noise from an environment of the body. The detection system receives a noise signal from the second microphone, and provides a resultant signal based on the auscultation signal and the noise signal. The detection system subtracts information from the auscultation signal to produce the resultant signal, where the subtracted information is based on the noise signal such that the subtracted information is based more on higher frequency ranges of the noise signal compared to a lower frequency range corresponding to the biological sounds.