Zhao, Xiao-Yan,Wang, Zhuozhi,Gu, Jian-Ming,Kim, Ji-Yun,Bauzon, Maxine,Murphy, John E.,McLean, Kirk,Jin, Fang,Marquardt, Tobias,Wang, Xinquan,Wilmen, Andreas
申请号：
AU2013352159
公开号：
AU2013352159A1
申请日:
2013.11.27
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
Provided herein are antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human activated Protein C (aPC) with minimal binding to its zymogen Protein C (PC). Moreover, these aPC binding proteins could potentially block the anti-coagulant activity of aPC to induce coagulation. Therapeutic uses of these binders are described herein as are methods of panning and screening specific antibodies.
