cDNA corresponding to the non-segmented negative chain RNA virus antigenome, and process for the production of such additional antigenically active protein coding viruses
BILLETER, MARTIN A.,SPIELHOFER, PIUS,KAELIN, KARIN,RADECKE, FRANK,SCHNEIDER, HENRIETTE
申请号：
ES96928446
公开号：
ES2239336T5
申请日:
1996.08.09
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
The present invention relates, in general, to a methodology for the generation of nonsegmented negative-strand RNA viruses (Pringle, 1991) from cloned deoxyribonucleic acid (cDNA). Such rescued viruses are suitable for use as vaccines, or alternatively, as plasmids in somatic gene therapy applications. The invention also relates to cDNA molecules suitable as tools in this methodology and to helper cell lines allowing the direct rescue of such viruses. Measles virus (MV) is used as a model for other representatives of the Mononegavirales, in particular the family Paramyxoviridae. <；IMAGE>；
