The invention relates to 4-(azetidin-1-yl)pyrimidyl compounds of formula (I),wherein X and Y are, independently of each other CH or N； U is O, CHOH, CHCH2OH, C(CH3)OH, CO, CHNH2； R1 and R2 are, independently of each other H, F or CH3； and R3 is H or CH3； and related compounds with anti-mitotic and anti-proliferative properties, and methods of making use of such compounds in therapy or diagnostics to attenuate undesired cell proliferation, growth, migration, metastasis tumor formation, and inflammatory conditions. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious and inflammatory diseases using such compounds.
