590890 Disclosed is an isolated antibody, or an antigen binding fragment thereof, that neutralizes infection of a group 1 subtype and a group 2 subtype of influenza A virus. Said antibody having the CDR sequences: GFTFSTYA, ISYDGNYK, AKDSQLRSLLYFEWLSQGYFDP, QSVTFNYKNY, WAS and QQHYRTPPT.