Батухтина Елена Викторовна (RU),Киселева Екатерина Владимировна (RU),Васильев Андрей Валентинович (RU),Решетов Игорь Владимирович (RU)
申请号：
RU2012138510/15
公开号：
RU00125464U1
申请日:
2012.09.10
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
A utility model may be used in partial or total arthroplasty of the larynx and / or trachea during surgical treatment of lesions or injuries arising from various diseases genesis. Tissue-implant is a bioengineering three-dimensional structure formed by laminating the cultured cells. The implant is made in the form of a bilayer elastic plate thickness of 2 to 5 mm. One of the layers of the implant formed from cultured chondrocytes or multipotential mesenchymal stromal cells of bone marrow or adipose tissue. It performs a carcass, a molding, an amortization function, and is an artificial analogue of the cartilage tissue. The second layer is formed of epithelial cells. It is a synthetic analogue of the epithelial tissue, a protective function, but also prevents the formation of scar tissue. Strength between structural components at the expense of cell-cell contacts and extracellular matrix proteins, cellular components of the synthesized design. The implant may additionally comprise a substrate of a biocompatible material. Design features provide an implant perform its most favorable adhesion to the defect area and eliminate the possibility of injury to adjacent tissues. This reduces the time of installation and adaptation of the implant. Furthermore, the implant design creates conditions for a recovery of combined cartilage defects and epithelial tissues injured organs of the upper respiratory tract due to the production of cell layers of tissue-implant components of the extracellular matrix of cartilage tissue andПолезная модель может быть использована при частичном или полном эндопротезировании гортани и/или трахеи в процессе хирургического лечения повреждений, возникающих при травмах или заболеваниях различного генеза. Тканеинженерный имплантат представляет собой трехмерную биоинженерную конструкцию, образованную наслоением культивированных клеток. Имплантат выполнен в форме двухслойной упругоэластичной пластины толщиной от 2 до 5 мм. Один из слоев имплантата сформ
