Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

IGAWA TOMOYUKI,ISHII SHINYA,MAEDA ATSUHIKO,NAKAI TAKASHI

申请号：

NZ60288409

公开号：

NZ602884A

申请日:

2009.04.10

申请国别(地区):

NZ

年份:

2014

代理人:

摘要：

A method for improving the pharmacokinetics of an antibody, the method comprising substituting at least one amino acid of the antibody with histidine, or inserting at least one histidine into the antibody, wherein the histidine substitution or insertion increases the KD(pH5.8)/KD(pH7.4) value, defined as the ratio of KD for the antigen at pH5.8 and KD for the antigen at pH 7.4, as compared to the KD(pH5.8)/KD(pH7.4) value before the histidine substitution or insertion.

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