PROBLEM TO BE SOLVED: To construct an FGFR-Fc fusion protein capable of antagonizing FGF.SOLUTION: A fusion protein comprises: a moiety of an intermediate functional sequence (IFS) of an Ig-like domain of FGFR, a second Ig domain (D2) of FGFR, a third Ig-like domain (D3) of FGFR, and an immunoglobulin Fc region.SELECTED DRAWING: Figure 1