An I.V. infusion or blood collection apparatus comprises an I.V. infusion set (100) and a safety shield (200). The I.V. infusion set has a wing body (105) from which a pair of wings (140) extend outward there from and a grip (145) extending upward there from. One end of the wing body mounts a needle (120) or catheter and medical tubing (130) is connected to the opposite end. The wing body includes a bore so that fluid flows between the needle and the medical tubing. A safety shield has a top, a bottom and opposing side walls and defines a cavity (227) that is adapted to receive the I.V. infusion set. The safety shield has slots (250) in each of the side walls and a slot (255) in the top. The respective wings and grip are adapted to be positioned in the slots and to slidably move therein. The slot in the top includes a lock that is adapted to receive the grip so that when the needle is retracted into the cavity the grip is permanently captured therein, thus locking the needle in the fully retracted safety position.