Marco Baratella,Giuseppe Pallanza,Mauro Gaboardi,Graziano Castaldi
申请号：
US14923875
公开号：
US09428468B2
申请日:
2015.10.27
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A process for the preparation of Erlotinib is disclosed in which the compound of formula (II)Is reacted with the compound of formula (III) in the presence of trifluoroacetic acid and formamidine acetate, in an aprotic solvent,and the reaction product is subsequently treated with a source of hydrochloric acid in a suitable solvent to give Erlotinib hydrochloride.
