FLUID VACCINES WITH COMBINATIONS OF PARTICLE ADJUVANTIES AND IMMUNE AMPLIFIERS

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专利权人:

NOVARTIS VACCINES AND DIAGNOSTICS S.R.L.

发明人:

RAPPUOLI, RINO,O'HAGAN, DEREK,DEL GUIDICE, GUISEPPE

申请号：

AT06808428

公开号：

AT539765T

申请日:

2006.11.06

申请国别(地区):

AT

年份:

2012

代理人:

摘要：

Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition comprising: (i) an influenza virus antigen； (ii) an insoluble particulate adjuvant； and (iii) a immunopotentiator.

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