The present invention relates to the reduction of scarring in wounds. More particularly, it relates to compounds according to Formula 1 for use in methods of reducing scarring, to formulations which incorporate these compounds and to a method of treating wounds using such compounds and formulations so as to reduce scarring:wherein is a double bond or triple bond, preferably a double bond；A, B and C are the same or different and selected from CH2CH2, cis-CH=CH, trans-CH=CH and C=C；R1 and R2 are the same or different and selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C4-8 cycloalkyl, C4-8 cycloalkenyl, C6-12 aralkyl, C5-10 aryl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, C4-8 cycloalkyloxy, C4-8 cycloalkenyloxy, C6-12 aralkyloxy, C5-10 aryloxy, C1-7 carbamate, and C2-6 acyl；R3 is CO2R31, CONR32R33, CH2OR34, CH2NR35R36, CH2N3, CH2-X, CH2NO2, CH2SR37, COSR38, or 2,3,4,5-tetrazol-1-yl, wherein:R31 is H or C1-6 alkyl；R32 and R33 are the same or different and selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C4-8 cycloalkyl, C4-8 cycloalkenyl, C6-12 aralkyl, C5-10 aryl, OH, or C1-6 alkoxy；R34 is H, C1-6 alkyl, or C2-6 acyl；R35 and R36 are the same or different and selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C4-8 cycloalkyl, C4-8 cycloalkenyl, C6-12 aralkyl, C5-10 aryl, OH, or C1-6 alkoxy；X is F, Cl, Br or I；R37 and R38 are H or a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C4-8 cycloalkyl, C4-8 cycloalkenyl, C6-12 aralkyl, C5-10 aryl；R4 and R5 are the same or different and selected from H, C1-6 alkyl, OH, C1-6 alkoxy, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, C4-8 cycloalkyloxy, C4-8 cycloalkenyloxy, C6-12 aralkyloxy, C5-10 aryloxy, C1-7 carbamate, and C2-12 acyl, or together form a double bonded oxygen；D is (CR6R7)q or (CR6R7)qO, where q is 0-6； and R6 and R7 are the same or different and selected from H or C1-6 alkyl；E is CH3, or a cyclohexyl or phenyl ring optionally substituted with one or more substituen
