To provide pharmaceutical compositions for treating polypoidal choroidal vasculopathy.SOLUTION: A composition comprises, as an anti-C5 complement protein agent, an aptamer having the following sequence: fCmGfCfCGfCmGmGfUfCfUfCmAmGmGfCGfCfUmGmAmGfUfCfUmGmAmGfUfUfUAfCfCfUmGfCmG-3T, where fC and fU are 2'-fluoro nucleotides, mG and mA are 2'-OMe nucleotides, all other nucleotides are 2'-OH, and 3T represents inverted deoxy thymidine.SELECTED DRAWING: None【課題】ポリープ状脈絡膜血管症の治療のための医薬組成物の提供。【解決手段】以下の配列：ｆＣｍＧｆＣｆＣＧｆＣｍＧｍＧｆＵｆＣｆＵｆＣｍＡｍＧｍＧｆＣＧｆＣｆＵｍＧｍＡｍＧｆＵｆＣｆＵｍＧｍＡｍＧｆＵｆＵｆＵＡｆＣｆＣｆＵｍＧｆＣｍＧ－３Ｔ（式中、ｆＣおよびｆＵ＝２’－フルオロヌクレオチドであり、ｍＧおよびｍＡ＝２’－ＯＭｅヌクレオチドであり、全ての他のヌクレオチドは２’－ＯＨであり、３Ｔは逆位デオキシチミジンを示す）を有するアプタマーを抗Ｃ５補体タンパク質剤として含む組成物。【選択図】なし
