isolated polypeptide, pharmaceutical composition, method for protecting, maintaining or enhancing the viability of an isolated responsive cell, tissue or organ of the mammalian body, use of an isolated polypeptide, method for facilitating transcytosis of a molecule, isolated nucleic acid, vector, host cell, and method for recombinantly producing the isolated polypeptide
<；b>； isolated polypeptide, pharmaceutical composition, method for protecting, maintaining or enhancing the viability of an isolated mammalian body responsive cell, tissue or organ, use of an isolated polypeptide, method for facilitating the transcytosis of a molecule, isolated nucleic acid. , vector, host cell, and method for recombinantly producing the isolated polypeptide <；d>； The present invention is directed to novel tissue protective peptides. The tissue protective peptides of the invention may bind to a tissue protective receptor complex. In particular, the present invention is directed to tissue protective peptides derived from or sharing consensus sequences with portions of cytokine receptor ligands, including erythropoietin (epo), which are not involved in ligand binding to the receptor complex, for example. to the epo receptor homodimer. therefore, the tissue protective peptides of the invention are derived from the amino acid sequences of cytokine receptor ligand regions that are generally located on or within the region of the ligand protein that is opposite to the receptor complex, that is, they are generally derived. amino acid sequences of regions of the ligand protein that are directed away from the receptor complex while the ligand is bound to the receptor. The invention is further directed to consensus sequences for engineering use of a synthetic tissue protective peptide. These tissue protective peptides also include fragments, chimeras, as well as peptides designed to mimic the spatial location of key amino acid residues within the tissue protective receptor ligands, for example epo. The invention further encompasses methods for treating or preventing disease or disorder using tissue protecting peptides of the present invention. The invention also encompasses methods for enhancing excitable tissue function using tissue protecting peptides of the present invention.<；b>；polipeptídeo isolado, composição farmacêutica, método para proteg
