The present invention relates generally to methods and compositions for prophylaxis and treatment of skin conditions. Topical compositions which protect the skin from UV radiation damage and treat UV radiation damage done to the skin are provided according to embodiments of the present invention which include at least one cyanin derived from a plant and at least one additional agent selected from the group consisting of: a UV radiation reflector, a UV screening agent, niacinamide, and a combination of two or more thereof.