The present invention discloses to combination use of EGFR/HER2 inhibitor and pyrimidine anti-metabolic drugs, specifically, the present invention relates to combination use of EGFR/HER2 receptor tyrosine kinase inhibitor and pyrimidine anti-metabolic drugs in the preparation of a medicament for the treatment of cancer.本發明公開EGFR/HER2抑制劑聯合嘧啶類抗代謝藥物的用途,具體涉及一種EGFR/HER2受體酪胺酸激酶抑制劑聯合嘧啶類抗代謝藥物在製備治療癌症的藥物中的用途。