WOLFGANG NEUBERGER,VOLKER ALBRECHT,GERHARD WIELAND,BURKHARD GITTER
申请号：
MX2012008386
公开号：
MX2012008386A
申请日:
2011.01.13
申请国别(地区):
MX
年份:
2013
代理人:
摘要：
Present invention provides enhanced methods and improved devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids. In preferred embodiments, present invention provides an antimicrobial PDT treatment and devices that effectively inactivates, reduces and/or destroys both Gram (-) and Gram (+) bacteria in complex body fluids. Preferred device embodiments comprise guiding channels and at least one electromagnetic radiation source, arranged separately or in sequence. Preferably, laser device or LED-panels are used to deliver electromagnetic radiation to activate the photosensilizer. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. When used with preferred photosensitizer composition based on Safranin O, preferred laser radiation wavelength is in the range of 500-580nm. Additionally, present invention diminishes adverse hosts inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it.La presente invención provee métodos mejorados y aparatos mejorados para eliminar, reducir, destruir y/o inhibir especies no deseadas de fluidos corporales, tales como microbios patógenos y células deterioradas o malignas en medios complejos como la sangre, el suero y otros fluidos corporales. En realizaciones preferidas, la presente invención proporciona un tratamiento de PDT antimicrobiana y aparatos que inactivan, reducen y/o destruyen en forma eficaz bacterias Gram (-) así como Gram (+) en fluidos corporales complejos. Las realizaciones de aparatos preferidas comprenden canales de guía y por lo menos una fuente de radiación electromagnética, dispuesta por separado o en secuencia. Preferentemente, el aparato láser o los paneles de LED se usan para suminis
