The present invention relates to a method to manufacture a pill and a concentrate for health improvement by using Senticosus and Sigesbeckia glabrescens Makino. The method comprises: a first process of boiling 100 parts by weight of a mixture, which is obtained by washing and cutting Senticosus and Sigesbeckia glabrescens Makino and then mixing the ingredients at a weight ratio of 1:1, in a container of water at 85-170°；C for 1-8 hours until the water becomes 2/3-1/4 of the initial amount, and then, filtering a solid and manufacturing only a concentrate； a second process of manufacturing leaf powder by smashing leaves of Senticosus and Sigesbeckia glabrescens Makino； a third process of mixing a mixture of at least two ingredients, which are selected from among kalopanax, oriental raisin tree, gastrodia, Senticosus, Sigesbeckia glabrescens Makino, thistles, mulberry tree, Oriental arbor vitae, Sweet wormwood, False daisy, hemp seeds, dried clove buds, Dictamnus albus, Veratrum maackii Regel var. japonica (Baker) T. Shimizu, Ceramiaceae, Huttuynia cordata, perilla frutescens, green tea, dong quai, and Northern bamboo, with sugar at a weight ratio of 1:1, and then, aging the mixture for 3-6 months to manufacture a viscous aged solution； and a fourth process of manufacturing a pill by mixing the concentrate, the leaf powder, and the aged solution, which are obtained through the first, second, and third processes, at a weight ratio of 1 : 2 : 0.1-0.3. As such, the present invention is capable of delivering excellent effects for chronic fatigue syndrome, stamina improvement, liver function improvement, learning ability, memory power, and diseases such as rheumatism, high blood pressure, cardiac disorders, eczema, and tumors.COPYRIGHT KIPO 2017본 발명은 가시오가피와 진득찰을 세척하여 잘게 썰어서 중량비 1: 1로 혼합하여 얻어진 혼합물 100중량부를 물이 담긴 용기에 넣어 가열기를 이용하여 85~170℃로 1~8시간 가열하여 물의 양이 최초의 양보다 2/3~1/4이 될 때까지 끓인다음 고형물을 걸러내고 농축액만을 제조하는 제 1공정과, 가시오가피잎 또는 진득찰잎, 이들이 혼합된 잎을 분쇄하여 잎분말을 제조하는 제2공정과, 엄나무, 헛개나무, 천마,
